XenoTech, LLC in Lenexa, KS, US (United States)

There are many examples of drugs that are potent inhibitors of human CYP enzymes but do not inhibit the corresponding animal CYPs, and vice versa. Therefore, to predict clinical drug inhibition, it is important to evaluate the potential inhibitory effects of NMEs with human liver microsomes. 

is dedicated to providing the highest quality GLP in vitro drug metabolism and drug-drug interaction studies to pharmaceutical and chemical companies worldwide. 

REACTION PHENOTYPING Determining if a drug is a CYP substrate and, if so, identification of the CYP enzyme(s) involved in its bio-transformation can help predict and avoid pharmacokinetic variability, and minimize adverse drug reactions. 

Ah receptor: The receptor (DNA-binding protein or transcription factor) that mediates the induction of CYP1A enzymes by agents such as b-naphthoflavone, 3-methylcholanthrene, Aroclor 1254 and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Ah receptor stands for aromatic hydrocarbon receptor. 

Madan A, Usuki E, Burton LA, Ogilvie BW and Parkinson A: In vitro approaches for studying the inhibition of drug-metabolizing enzymes and identifying the drug-metabolizing enzymes responsible for the metabolism of drugs.